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KMID : 0616120120430020122
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Korean Journal of Pharmacognosy
2012 Volume.43 No. 2 p.122 ~ p.126
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Cholinesterase Inhibitors Isolated from the Fruits Extract of Evodia officinalis
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Lee Ji-Young
Cha Mi-Ran
Choi Chun-Whan
Kim Young-Sup
Lee Bong-Ho
Ryu Shi-Yong
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Abstract
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The MeOH extract of Evodiae Fructus exhibited a significant inhibition on the acetylcholinesterase (AChE) and
butyrylcholinesterase (BChE), in a dose dependent manner, respectively. The extensive bioactivity-guided fractionation process with the MeOH extract finally isolated four compounds, as rutaecarpine (1), evodiamine (2), limonin (3) and dehydroevodiamine (4). Among them, compound 2 exhibited specific inhibitory activity on BChE with the IC50 values 1.7 μg/ml, whereas compound 4 showed the potent inhibition upon both AChE and BChE.
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KEYWORD
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Evodia officinalis, Rutaceae, inhibition, Acetylcholinesterase, Butyrylcholinesterase
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